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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in grown-ups with a body mass index (BMI) in excess of 27, so long as they also have problems with weight-related health issues such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure).Contrave is often a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so when an aid to quitting smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle that includes a reduced-calorie exercise and dieting, Contrave provides another treatment selection for chronic weight loss for people who are obese or are overweight and possess at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical exercise. Results from a clinical study that enrolled patients without diabetes showed that patients had a normal weight loss of four years old.1% rather than participants who were given placebos) throughout a 12- month period, while a separate study involving patients with diabetes type 2 had an average weight loss of 2% over treatment with placebo at one full year.

Using two separate drugs to shed weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people that go through it you need to err assisting caution and let the FDA do its job and demand some investigation be done so that the public is aware of the side effects and risks of the medications before we drive them. Keep in mind that drug companies come in business to generate money and that they would say anything to keep people on their medications.

Researchers found that participants taking this drug for the year, dropped excess weight within one month and have kept the extra weight off during the entire 56 weeks of the study. Contrave is a combination from the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs which can be made up of multiple active ingredient, which can make them more efficient and safer.

Combo-pilling is the newest fad or better yet the newest in the future under scrutiny and therefore it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular is the fact that by right now there aren't long term prescription slimming capsules that have been licensed by the FDA aside from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug may also raise hypertension and heartbeat, and shouldn't be used in people who have a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise hypertension and heartrate and must not used in patients with uncontrolled high blood pressure, in addition to by you are not heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients which has a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients to the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.


"There were no warning signs of depression or suicidal thoughts in trial participants," said Fujioka.